All about rhabdomyolysis  causes of rhabdomyolysis symptoms of rhabdomyolysis treatment for rhabdomyolysis |
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What causes rhabdomyolysis?
A large number of drugs may cause rhabdomyolysis through several mechanisms, such as myotoxicity (for example, animal toxins, antibiotics, statins, alcohol, etc), circulatory ischemia, hyperpyrexia, long duration muscle rigidity and others.
Drug-induced rhabdomyolysis is more common nowadays than in the past, due to the introduction of increasingly more potent drugs into clinical practice. Any drug which directly or indirectly impairs the production or use of adenosine triphosphate (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis.
Myoglobin is an oxygen-binding protein pigment found in the skeletal muscle. When the skeletal muscle is damaged, the myoglobin is released into the bloodstream. It is filtered out of the bloodstream by the kidneys. Myoglobin may occlude the structures of the kidney, causing damage such as acute tubular necrosis or kidney failure. Myoglobin breaks down into potentially toxic compounds, which will also cause kidney failure. Necrotic (dead tissue) skeletal muscle may cause massive fluid shifts from the bloodstream into the muscle, reducing the relative fluid volume of the body and leading to shock and reduced blood flow to the kidneys. The disorder may be caused by any condition that results in damage to skeletal muscle, especially trauma. |
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More information on rhabdomyolysis
What is rhabdomyolysis? - Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber contents into the circulation.
What causes rhabdomyolysis? - Rhabdomyolysis is caused by myotoxicity, circulatory ischemia, hyperpyrexia, long duration muscle rigidity and others.
What're the symptoms of rhabdomyolysis? - Signs and symptoms of rhabdomyolysis include dark, red, or cola colored urine and muscle tenderness, stiffness, aching (myalgia) or weakness.
What's the treatment for rhabdomyolysis? - The treatment of rhabdomyolysis is primarily directed at preserving renal function. Ideal treatment involves early and aggressive hydration. |
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