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All about muscular dystrophy types of muscular dystrophy causes of Duchenne muscular dystrophy symptoms of Duchenne muscular dystrophy causes of Becker's muscular dystrophy symptoms of Becker's muscular dystrophy causes of limb-girdle muscular dystrophy symptoms of limb-girdle muscular dystrophy causes of facioscapulohumeral muscular dystrophy symptoms of facioscapulohumeral muscular dystrophy causes of myotonic dystrophy symptoms of myotonic dystrophy diagnosis of muscular dystrophy treatment for muscular dystrophy

What causes Duchenne muscular dystrophy (DMD)?

Duchenne muscular dystrophy is a rapidly progressive form of muscular dystrophy. It is caused by a defective gene, but it often occurs in people from families without a known family history of the condition. Duchenne muscular dystrophy is inherited in an X-linked recessive pattern. Because women have two X chromosomes, if one contains a normal copy of the

gene, that gene will make enough of the protein to prevent symptoms. But boys have an X chromosome from their mother and a Y from father, so if the X chromosome is defective, there is no second X to make up for it and they will develop the disease. It is marked by progressive loss of muscle function, which begins in the lower limbs. The cause of the muscle impairment is an abnormal gene for dystrophin (a protein in the muscles).

Duchenne's muscular dystrophy is an inherited disease of skeletal (voluntary) muscles and the most common form of childhood muscular dystrophy. It generally appears from age three to six years and worsens rapidly. At first, muscle weakness and wasting (atrophy) within the pelvic (hipbone) area occurs followed by similar problems in the shoulder muscles. Eventually, muscle weakness and atrophy affect the trunk and forearms and gradually spread to the major muscles of the body. From 20 to 30 boys of every 100,000 born are affected by Duchenne's muscular dystrophy. The sons of carrier females (women with one defective chromosome but no symptoms themselves) each have a 50% chance of having the disease, and the daughters each have a 50% chance of being carriers.

More information on muscular dystrophy

What is muscular dystrophy? - Muscular dystrophy is a group of inherited diseases that are characterized by weakness and wasting away of muscle tissue.
What types of muscular dystrophy are there? - There are nine types of muscular dystrophy including Duchenne muscular dystrophy, Becker muscular dystrophy, facioscapulohumeral muscular dystrophy.
What causes Duchenne muscular dystrophy (DMD)? - Duchenne muscular dystrophy is a rapidly progressive form of muscular dystrophy. It is caused by a defective gene.
What're the symptoms of Duchenne muscular dystrophy? - Symptoms of Duchenne muscular dystrophy include progressive muscle weakness of the legs and pelvis, mental impairment or heart problems.
What causes Becker's muscular dystrophy? - Becker muscular dystrophy is a type of dystrophinopathy which include a spectrum of muscle disease caused by mutations in the DMD gene.
What're the symptoms of Becker's muscular dystrophy? - Symptoms of Becker-type muscular dystrophy are similar to those of Duchenne dystrophy, but they are milder and begin later.
What causes limb-girdle muscular dystrophy? - Limb-girdle muscular dystrophy is an inherited disorder, it may be inherited as a dominant, recessive, or X-linked genetic defect.
What're the symptoms of limb-girdle muscular dystrophy? - Symptoms of limb-girdle muscular dystrophy include progressive muscle weakness in the shoulders and hips, together with breathing problems.
What causes facioscapulohumeral muscular dystrophy? - Facioscapulohumeral muscular dystrophy involves progressive muscle weakness and loss of muscle tissue.
What're the symptoms of facioscapulohumeral muscular dystrophy? - Symptoms of facioscapulohumeral muscular dystrophy may begin during infancy, late childhood, or early adulthood.
What causes myotonic dystrophy? - Myotonic dystrophy is caused by an inherited gene defect. Myotonic dystrophy is the most common form of adult muscular dystrophy.
What're the symptoms of myotonic dystrophy? - Symptoms of myotonic dystrophy include muscle weakness and wasting, cataracts, heart problems, constipation and other digestive problems.
How is muscular dystrophy diagnosed? - Diagnosis of muscular dystrophy involves a medical history and physical exam to determine the distribution of symptoms and to rule out other causes.
What's the treatment for muscular dystrophy? - Treatments for muscular include decreased mobility and dexterity, contractures, scoliosis, heart defects, and respiratory weaknesses.
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